Boosting levels of the neurotransmitter norepinephrine with atomoxetine, a repurposed ADHD medication, may be able to stall neurodegeneration in people with early signs of Alzheimer’s disease, according to a new study.
This is one of the first published clinical studies to show a significant effect on the protein tau, which forms neurofibrillary tangles in the brain in Alzheimer’s. In 39 people with mild cognitive impairment (MCI), six months of treatment with atomoxetine reduced levels of tau in study participants’ cerebrospinal fluid (CSF), and normalized other markers of neuro-inflammation.
The study points toward an alternative drug strategy against Alzheimer’s that does not rely on antibodies against tau or another Alzheimer’s-related protein, beta-amyloid. A recent FDA-approved drug, adacanumab, targets beta-amyloid but its benefits are controversial among experts in the field.
today i did a double feature of hop (2011) dir. tim hill and sonic the hedgehog (2020) dir. jeff fowler and i gotta say… james marsden is intimidatingly handsome and also has great chemistry with small talking cgi animal creatures
finding myself very invested in the James Marsden Chauffeuring Obnoxious Little CGI Creatures Cinematic Universe (JMCOLCCCU)
I showed this tiktok to my grandma to make her laugh, but now she’s all excited and actually wants to make a chocolate potato cake. We’re gonna do it.
I’ll keep everyone posted.
It’s happening, folks!
Looks good, but we’re not done yet!
Our sweet, sweet child needs to cool before we add the finishing touches!
My creation is complete!
After dinner, we’ll give it a taste test!
I wonder how it’ll taste.
Oh…
My…
God.
It’s incredible!
This stupid cake, made with potatoes … is delicious! It’s so sweet, moist, and decadent, just like a brownie! And I don’t even like chocolate or potatoes!
The recipe from the tiktok was pretty much impossible to find. I looked high and low, but everyone posted recipes that I KNOW he didn’t use because the ingredients and methods were different. After some searching, my grandma and I came up with our own recipe.
For the Cake:
1 cup mashed potato
2 cups sour cream
1 ¾ cup flour
1 ¾ cup sugar
¾ cup unsweetened cocoa powder
½ cup softened butter
2 eggs
1 ½ tsp baking soda
1 tsp vanilla
Pinch of salt
For the Drizzle:
4 oz semi-sweet chocolate
½ cup sugar
3 tbsp corn syrup
2 tbsp water
A lot of recipes called for a mixer or a processor, but my grandma and I wanted to make an every-man kind of recipe, since we know not everyone has those things. Plus they’re heavy and a pain to clean anyway, so bowls it is!
Instructions:
1. Peel and boil the potato, then mash it. Set aside to cool. Go to the bathroom, do your homework, then come back. That should be enough time.
2. Set oven to 350°F.
3. Cream butter. This means putting the sugar and butter into a bowl and mashing it together with a fork until it’s thoroughly mixed.
3. Put everything else in the same bowl, including the mashed potato. Mix and stir well. Work those muscles!
4. Grease a pan (doesn’t matter what kind you use) and spatula batter into pan. Even out if necessary.
5. Bake in oven for 40 minutes.
6. Test cake with pick. If nothing sticks, it’s finished. If batter does stick to pick, let it bake a bit longer but make sure it doesn’t burn. Remove and set aside to cool.
For the Drizzle:
1. Cut chocolate into tiny squares.
2. In a small pot, mix sugar, corn syrup, and water.
3. On medium heat, wait for mixture to sizzle and stir it. Do NOT let it boil.
4. Remove from element and add chocolate.
5. Wait for squares to melt, then mix.
6. Drizzle or pour over cake.
Enjoy!
I’m so glad there’s a recipe now, I really want to try this!
Hey here is a thing that happened. We went for a simple ganache for the glaze. Heated 1 cup of cream till hot then poured over 1 cup of semisweet and 1 cup of milk chocolate chips. Whisk untill melted and pour over your chocolate mash potato cake
Found the original recipe! (Apparently it was listed as a caramel potato cake in the original recipe book??? Anyway, now there’s two CPC recipes!)
Chocolate Potato Cake
½ cup butter 1 cup sugar 2 eggs ½ cup milk ½ cup hot riced
potatoes [just pure potato, mashed, no milk or butter or pepper or salt or whatever, just pure mashed potato] 1 cup flour 2 tsp baking powder ½ tsp cinnamon ½ tsp clove ½ tsp nutmeg ½ cup grated chocolate ½ cup chopped nut
meats [optional, never ever feel pressured to add nuts to your
chocolate cake, our guy here didn’t!]
Just… put everything into the mixing bowl in that order, with lots of mixing in between each addition.
Into a greased and/or lined tin, and then into a moderate oven for 55 minutes (or until cooked).
Frosting
2 Tbs butter 1 cup sugar ¼ cup milk 1 square unsweetened
chocolate ½ tsp vanilla [also optional, since again, not mentioned by our maker here!]
Boil, but be careful it doesn’t burn. …Basically? Stir constantly! (also, apparently the vanilla only gets added after the mix is taken off the heat…)
He did a long-form! He explained the steps!
is this how I learn that this legend has a youtube channel???
